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VU 0240551

CAS No. 893990-34-6

VU 0240551( VU0240551 )

Catalog No. M16441 CAS No. 893990-34-6

VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    VU 0240551
  • Note
    Research use only, not for human use.
  • Brief Description
    VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
  • Description
    VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells; displays >100-fold selectivity over NKCCl; also shows significant inhibition (>50% at 50 μM) of several GPCRs and key ion channels (hERG and L-Type Ca2+ channels).
  • In Vitro
    VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner with 75 and 100 μM treatments causing a significant reduction in GABA-elicited hyperpolarization while 25 μM had no significant effect.
  • In Vivo
    VU 0240551 (10 μM) significantly blocks the chloride influx in cells from Eu rats but did not affect cells from SL rats.
  • Synonyms
    VU0240551
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    893990-34-6
  • Formula Weight
    342.43
  • Molecular Formula
    C16H14N4OS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL 146.01 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(NC1=NC(C)=CS1)CSC2=NN=C(C3=CC=CC=C3)C=C2
  • Chemical Name
    N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Deisz RA, et al. Neuroscience. 2014 Sep 26;277:831-41. 2. Chevy Q, et al. J Neurosci. 2015 Dec 2;35(48):15772-86.
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